Basic Information
VIS ID
TVIS44026226
Fusion event
HTLV-1-SMARCA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
2087382/2087382 (Hg38)
End
2087382/2087382 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMARCA2
miRNAs that regulate target gene
hsa-mir-199a-3p ; hsa-mir-199a-5p ; hsa-mir-186-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-19b-3p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-1302-9/Upstream/2057101; hsa-let-7a-1/Downstream/2762915;
Nearest TSS
ENST00000422679/Upstream/360; ENST00000636758/Downstream/9219;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/39581, chr9-CpG: 24/Downstream/153955
Nearest cancer related gene
SMARCA2(TSG, No orient, 0)
Upstream sequence
CCCTTTGTCTTTTGCCAGCATGTTTACCAGGCTACCAGAAAAGGGTCCCAACCGGTGGAATGCTTAACTGCAGTGGGCCACAGGGAGGATGAACATGGAG
Downstream sequence
ATATTTTGCTGAAGTAATTTAACCAGACCAAATTAACCAACTAAATACAAGCTTTAAACAAATCTTTCCTTGTTACAAACTTGGAGTTCCCTTTAAAATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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