Basic Information
VIS ID
TVIS44026256
Fusion event
HTLV-1-KANK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
488826/488826 (Hg38)
End
488826/488826 (Hg38)
Orient
-
Location type
Intronic
Target gene
KANK1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-335-5p ; hsa-mir-10a-5p ; hsa-mir-100-5p ; hsa-mir-374b-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-633 ; hsa-mir-3622b-5p ; hsa-mir-873-5p ; hsa-mir-3677-5p ; hsa-mir-646 ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-503-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1302-9/Upstream/458545; hsa-let-7a-1/Downstream/4361471;
Nearest TSS
ENST00000422679/Upstream/17359; ENST00000354485/Downstream/3422;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/18502, chr9-CpG: 215/Downstream/15110
Nearest cancer related gene
KANK1(TSG, No orient, 0)
Upstream sequence
TCAGGATTCACTCTTACTGCTGCCTGTTATGTACAATCTCAAGCAGTGTTGTTTATTATTATTCTAAGAATAGCATAGCTTTTGGGTCTGTATTTTACAA
Downstream sequence
ACCAAATATTGTAATTTTAGGGATAATGGAATATTAGGGGCATAATGGGGAAAGTTGAAAAATTATGGTCAGTGGagagatagttaaaaaaaaagtactg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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