Basic Information
VIS ID
TVIS44026265
Fusion event
HTLV-1-RORB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77230764/74615848 (Hg38)
End
77230764/74615848 (Hg38)
Orient
+
Location type
Intronic
Target gene
RORB
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-519d-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-101-2/Upstream/3805764; hsa-let-7a-1/Downstream/9353900;
Nearest TSS
ENST00000422679/Upstream/248; ENST00000455609/Downstream/218209;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/116837, chr9-CpG: 48/Downstream/271329
Upstream sequence
GTGGGGACAAAAAAATATTTTCTGACTCAGGAATGTATATAATAAAACAAGTCACTCAGGCTTAATTTTACACTGGAGAAGATATTTATATATAAATACT
Downstream sequence
GTCATATCCTGGAGTGAACTACCAAATGCATAAGTTTCAAGATTAAATTCAAGTCGTTATCCACCACATTATACTAACATTAGGTTAATCATATGAACAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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