Basic Information
VIS ID
TVIS44026269
Fusion event
HTLV-1-PRUNE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
79506364/76891448 (Hg38)
End
79506364/76891448 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRUNE2
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-196a-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-769-5p ; hsa-mir-382-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-4671-3p ; hsa-mir-593-5p ; hsa-mir-6124 ; hsa-mir-4733-3p ; hsa-mir-3148 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-4796-3p ; hsa-mir-548m ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-130a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/6081364; hsa-let-7a-1/Downstream/7078300;
Nearest TSS
ENST00000422679/Upstream/22266; ENST00000376708/Downstream/14593;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/431803, chr9-CpG: 75/Downstream/14439
Upstream sequence
GTGACATCCAGTCACCTGTTGTCCCATTACAGGCATGTCAGGTGATGCCCACAGGCCCTCCAGAGACCCTGCCTCTCAGGTGCCTTCTTTCCATTACAGG
Downstream sequence
TGACACTTAGTCTCCAGAGCCTGTTGGGCTCAGCATGTTTCCACCAGTGACACATTCATTAATCTCACAGTTGCATACTGTACATCAGAGTCCATCACAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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