Basic Information
VIS ID
TVIS44026298
Fusion event
HTLV-1-SYK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
93596783/90834501 (Hg38)
End
93596783/90834501 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9D
Target gene
SYK
miRNAs that regulate target gene
hsa-mir-99b-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-4279 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-6778-3p ; hsa-mir-3199 ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-3653-5p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4643 ; hsa-mir-4740-3p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-498 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-1468-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-3182 ; hsa-mir-203a-3p ; hsa-mir-4766-5p ; hsa-mir-5190 ; hsa-mir-486-3p ; hsa-mir-532-5p
Nearest miRNA
hsa-mir-101-2/Upstream/810966; hsa-let-7a-1/Downstream/801750;
Nearest TSS
ENST00000422679/Upstream/7013; ENST00000563268/Downstream/130892;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/32237, chr9-CpG: 61/Downstream/282942
Nearest cancer related gene
SYK(TSG, No orient, 0)
Upstream sequence
CCCCTTTCACCAGTGAAGAACTCTATTGCTATAGTGCCCAGGTCACACAAAGCTGGGCCGGGTCGCCAGCGTTCCCGATTCTCACCTCTGTGTCCCTGGG
Downstream sequence
TTTCCTGCTCTCTGGCCCAGTGGAACCACCTCCACGGGGTACCATTCCTTTCCAGCCTTGTCTTTTGTTCATTGGCAATGATGTTAACAAATTAAATAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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