Basic Information
VIS ID
TVIS44026360
Fusion event
HTLV-1-GRK5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
121157443/119397931 (Hg38)
End
121157443/119397931 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
GRK5
miRNAs that regulate target gene
hsa-mir-941 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-4481 ; hsa-mir-4745-5p ; hsa-mir-570-3p
Nearest miRNA
hsa-mir-107/Upstream/19888; hsa-mir-202/Downstream/560582;
Nearest TSS
ENST00000439456/Upstream/61749; ENST00000369108/Downstream/54517;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/189820, chr10-CpG: 181/Downstream/144035
Upstream sequence
GCCCCACTCTGGACAGCCTGCTAGACGGCATTCCTAATGCGCACACAGTCGCCATCACCTTGTTGCCTCCCCTTGCTGTTTCTCTGCTGCATCCATCATA
Downstream sequence
ATCCATGCACTTCTCTTTCTGTGAACTGCAAACACCCCCAGCCCTTTTGCACTTTTCAGAAATGACAGAATTTATGTTTATAAAACACTTCTAGGCATAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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