Basic Information
VIS ID
TVIS44026362
Fusion event
HTLV-1-PLPP4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.12
Reference genome
GRCh37/hg19
Start
122343525/120584013 (Hg38)
End
122343525/120584013 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
PLPP4
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-455-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-3925-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-1273g-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-508-5p
Nearest miRNA
hsa-mir-107/Upstream/625421; hsa-mir-202/Downstream/1832952;
Nearest TSS
ENST00000439456/Upstream/8825; ENST00000623529/Downstream/13936;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/126148, chr10-CpG: 32/Downstream/267153
Upstream sequence
TAGATGGCAGGCCAGAGAGAGAGCAGGTCCCCTGGTCCATGCTGAGGGCTCCACAGAGCCACAAAGGGACATGGAAAACATTCTGCTCCAGCCCATACCA
Downstream sequence
GATGACTGGTCAATTTGTGTCCTGTAGTCTTACAAAGACACTACCCCTTTCTTAAAAGATGggtctatcttcagtttctcagatttaccaagcctccttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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