Basic Information
VIS ID
TVIS44026369
Fusion event
HTLV-1-LHPP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
126176843/124488274 (Hg38)
End
126176843/124488274 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
LHPP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3650 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-5093 ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-1247-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-665 ; hsa-mir-7160-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-5584-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-1273g-3p ; hsa-mir-1825 ; hsa-mir-3130-3p ; hsa-mir-3160-3p ; hsa-mir-3187-3p ; hsa-mir-4252 ; hsa-mir-4435 ; hsa-mir-4487 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4701-5p ; hsa-mir-5186 ; hsa-mir-548s ; hsa-mir-558 ; hsa-mir-588 ; hsa-mir-6499-3p ; hsa-mir-6516-5p
Nearest miRNA
hsa-mir-107/Upstream/2071207; hsa-mir-202/Downstream/544509;
Nearest TSS
ENST00000439456/Upstream/26431; ENST00000487190/Downstream/155;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/26103, chr10-CpG: 17/Downstream/101455
Upstream sequence
TTGGGATGGAGGGTCCTGGGTGTGTCCACCTTTCTCCTCATAAGCcctctctgaggagccgaattccctcctctgtcaaataggaataacccttctgtgt
Downstream sequence
ctacctcccatggcagctgtgatgatcagaaagaaatgcatctgagaAAGGGGGAGGACATGTGAAAGGTGTCCCTGGTAGGAGATGGGGAGGTAGGCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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