Basic Information
VIS ID
TVIS44026373
Fusion event
HTLV-1-ADAM12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
127837582/126149013 (Hg38)
End
127837582/126149013 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
ADAM12
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-1-3p ; hsa-mir-218-5p ; hsa-mir-135b-5p ; hsa-mir-29a-3p ; hsa-mir-29c-3p ; hsa-mir-30b-3p ; hsa-mir-30d-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-1185-5p ; hsa-mir-1224-5p ; hsa-mir-129-5p ; hsa-mir-1304-5p ; hsa-mir-33a-5p ; hsa-mir-33b-5p ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-3915 ; hsa-mir-4689 ; hsa-mir-586 ; hsa-mir-6858-5p ; hsa-mir-8055
Nearest miRNA
hsa-mir-107/Upstream/329191; hsa-mir-202/Downstream/3694286;
Nearest TSS
ENST00000439456/Upstream/39225; ENST00000473861/Downstream/6292;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/252044, chr10-CpG: 132/Downstream/238573
Upstream sequence
TGCTGCCTAGAGGACTCCATGGAGGGAGGGAGGGGCAAGTCTCACCCACTACTGACCTCAAGGGCTGCCCAACACAGGGGCTGCAGCCACTCCCCAGTTA
Downstream sequence
GCAGGGACCAGGGATTTTCAGGGCCTGTCTCCTCCCACCCTCTTCCCTGTAAAGAGACAGTTCCATGGGGAGGACCGGGGGAAGACGAGGGGAATGGAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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