Basic Information
VIS ID
TVIS44026376
Fusion event
HTLV-1-DOCK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
128889540/127091276 (Hg38)
End
128889540/127091276 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
DOCK1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-183-5p ; hsa-mir-155-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-6867-5p ; hsa-mir-31-5p
Nearest miRNA
hsa-mir-107/Upstream/1271454; hsa-mir-202/Downstream/2752023;
Nearest TSS
ENST00000439456/Upstream/64769; ENST00000473861/Downstream/18969;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/184797, chr10-CpG: 32/Downstream/84050
Upstream sequence
gtttcaccatgttagccaggatggtctcgatctcctgacctcgcgatccgcccgacttggcctcccaaagtgctgggattacaggcgtgagccactgcgc
Downstream sequence
ccagcctgaacgtctatttttaattcttttgggtatacatcgaggagtgaaactgctgggtcTGTTTCTGTTGAGTTGACTGAAGAAAGGATATTCGTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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