Basic Information
VIS ID
TVIS44026394
Fusion event
HTLV-1-ADARB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
1643540/1601345 (Hg38)
End
1643540/1601345 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADARB2
miRNAs that regulate target gene
hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-144-5p ; hsa-mir-4795-5p ; hsa-mir-34c-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4295 ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3117-5p ; hsa-mir-6776-3p ; hsa-mir-4753-5p ; hsa-mir-6768-3p ; hsa-mir-497-3p ; hsa-mir-2681-5p
Nearest miRNA
hsa-mir-5699/Upstream/959567; hsa-mir-107/Downstream/474674;
Nearest TSS
ENST00000439456/Upstream/74582; ENST00000435539/Downstream/136131;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/47748, chr10-CpG: 178/Downstream/97885
Upstream sequence
AGTGGTCACTGGAGCCCAGGCGTCAATGACCAAGTGGAAGATAGGCCAGGTGGGCCCCCACTGGTGGCCATCGGACAGAATCCAGGTTCGGCTCTGCAGT
Downstream sequence
GTGGGTCTAAGTTAACTTTAGTCCAGTTTTCTTGCCAGCATGCCCTTCTCACAGTAAACGGTTTCCTGTGCCCTGAAGGAATCTCCCCATCTCAGCCTTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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