Basic Information
VIS ID
TVIS44026451
Fusion event
HTLV-1-ARHGAP22 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
49657407/48449364 (Hg38)
End
49657407/48449364 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
ARHGAP22
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-615-3p ; hsa-mir-421 ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-4709-5p ; hsa-mir-1178-5p ; hsa-mir-5580-5p ; hsa-mir-202-3p ; hsa-mir-149-5p ; hsa-mir-4267 ; hsa-mir-1207-3p
Nearest miRNA
hsa-mir-1265/Upstream/3285276; hsa-mir-107/Downstream/536148;
Nearest TSS
ENST00000439456/Upstream/19471; ENST00000360890/Downstream/2263;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/142007, chr10-CpG: 86/Downstream/817
Upstream sequence
GTCCTTCCAGCCCTGGCTCAGGCACTGCCTGCTGTGACTTCCCCCATGGCAGAGGCCTCTGCCCTCAAGGTCCCTCTCCTTCTCTTCCTTTTGCAGACAT
Downstream sequence
GGTGCCTGTACATGCCTGGCACTCTCCATCACCCAGGGAACAGCTGTCAGCAGAGCAAAAGGGCAAGGGCTGCCATTCCAGCTCCCAGTGGAAATCACAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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