Basic Information
VIS ID
TVIS44026475
Fusion event
HTLV-1-MCU integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
74534121/72774363 (Hg38)
End
74534121/72774363 (Hg38)
Orient
-
Location type
Intronic
Target gene
MCU
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-10a-5p ; hsa-mir-23a-3p ; hsa-mir-629-3p ; hsa-mir-3977 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6749-3p ; hsa-mir-623 ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-4469 ; hsa-mir-136-5p ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4716-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-1178-5p ; hsa-mir-139-3p ; hsa-mir-25-5p ; hsa-mir-4795-5p ; hsa-mir-658 ; hsa-mir-873-5p
Nearest miRNA
hsa-mir-1265/Upstream/53263; hsa-mir-107/Downstream/2778095;
Nearest TSS
ENST00000439456/Upstream/62059; ENST00000483185/Downstream/85632;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/81524, chr10-CpG: 103/Downstream/321737
Upstream sequence
gatggagttaaagcatagaattctttttttgttttacctttgtttgtgtatttttgatctaagttctcatctctttaaaatagcttcttatgtctgtaag
Downstream sequence
atgttttttgtaagcctcatggtaaccagagtacaaaaacctataatagacttactaaaaacacaacaaattaaaaacagattactagggaaagtcactt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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