Basic Information
VIS ID
TVIS44026498
Fusion event
HTLV-1-MARCH5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
94081782/92322025 (Hg38)
End
94081782/92322025 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
MARCH5
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-let-7e-5p ; hsa-mir-34a-5p ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-4719 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-mir-107/Upstream/2729198; hsa-mir-1287/Downstream/3742290;
Nearest TSS
ENST00000439456/Upstream/13547; ENST00000462465/Downstream/11482;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/30370, chr10-CpG: 42/Downstream/98533
Upstream sequence
tttttctggtcagtctagctaaagatttgtcagggttggccaggcgtggtggctcatgcctgtaatcccagcactttgggaggccgaggcgggcggatca
Downstream sequence
cctgaggtcgggagttcaagaccagcctgaccaacatggaaaaaccccgtctctactaaaaatataaaattagccgggcatggtggcgggcacctataat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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