Basic Information
VIS ID
TVIS44026501
Fusion event
HTLV-1-HELLS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
96372105/94612348 (Hg38)
End
96372105/94612348 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
HELLS
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-193b-3p ; hsa-mir-124-3p ; hsa-let-7b-5p ; hsa-mir-877-3p ; hsa-mir-769-5p ; hsa-mir-615-3p ; hsa-mir-607 ; hsa-mir-6895-3p ; hsa-mir-138-2-3p ; hsa-mir-205-3p
Nearest miRNA
hsa-mir-107/Upstream/5019521; hsa-mir-1287/Downstream/1451967;
Nearest TSS
ENST00000439456/Upstream/15468; ENST00000339022/Downstream/71273;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/66212, chr10-CpG: 63/Downstream/571090
Nearby gene
HELLS(+10249) ;
Upstream sequence
acctATTATAAGAAACTCAGTGTTGCTGCAATGTATGTATTATAATGGATTTGAAATTTGCCCTAACCAAGAGTCACAGACAGAAAAAAGGAAGTTAATG
Downstream sequence
TATCTCTTGATCACTATCAAGATGTGGTATTGAACcttcaagatccttttcagggaatatgtgagatcaaaatttttatactggcactatgatgttattt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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