Basic Information
VIS ID
TVIS44026509
Fusion event
HTLV-1-ARHGAP42 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100698003/100827272 (Hg38)
End
100698003/100827272 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP42
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-28-5p ; hsa-mir-222-3p ; hsa-mir-138-5p ; hsa-mir-376c-3p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-4299 ; hsa-mir-3692-5p ; hsa-mir-4633-3p ; hsa-mir-6071 ; hsa-mir-6500-5p ; hsa-mir-587 ; hsa-mir-6131 ; hsa-mir-3185 ; hsa-mir-133a-5p ; hsa-mir-93-3p ; hsa-mir-885-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-4511
Nearest miRNA
hsa-mir-10392/Upstream/4485746; hsa-let-7a-2/Downstream/692548;
Nearest TSS
ENST00000527297/Upstream/56906; ENST00000525558/Downstream/12132;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/139602, chr11-CpG: 170/Downstream/300027
Upstream sequence
ttgtatttttagtagagatggggtttcacaatgttggccaggctggtctcaaactcctgacctcaagtgattcacccatcttagcctctcaaaatgctgg
Downstream sequence
gattacaggcatgagccacaacgtccggccAAGCCTTACATCTTTACATAGAGTGATGGGACCTTCAATGGAATCACTTGGAAAACACCATGTGATTTTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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