Basic Information
VIS ID
TVIS44026512
Fusion event
HTLV-1-DYNC2H1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103048307/103177578 (Hg38)
End
103048307/103177578 (Hg38)
Orient
+
Location type
Exonic
Target gene
DYNC2H1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10392/Upstream/1657673; hsa-let-7a-2/Downstream/672328;
Nearest TSS
ENST00000527297/Upstream/68003; ENST00000533027/Downstream/27333;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/85258, chr11-CpG: 43/Downstream/859099
Upstream sequence
AGTGTTACAGAATAAAAGCAGAACTAAGTATGATTGAATATTATAAATCATATATGAACATATTTCTTTCCTACTAGATCAAAAAGGCTTTAGAATTGTA
Downstream sequence
TGAACAGTTATGCCAGAGGATGGGAGTTGTTATTGTTGGTCCAAGTGGTGCTGGAAAATCAACGCTTTGGAGAATGTTAAGGGCTGCGCTTTGTAAAACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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