Basic Information
VIS ID
TVIS44026537
Fusion event
HTLV-1-MCAM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
119185049/119314339 (Hg38)
End
119185049/119314339 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
MCAM
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-573 ; hsa-mir-329-3p ; hsa-mir-5698 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-4294 ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-891a-3p ; hsa-mir-564 ; hsa-mir-5693 ; hsa-mir-1277-5p ; hsa-mir-335-3p ; hsa-mir-5007-3p ; hsa-mir-190a-3p ; hsa-mir-340-5p ; hsa-mir-5011-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-5580-3p ; hsa-mir-410-3p
Nearest miRNA
hsa-mir-10392/Upstream/1327; hsa-let-7a-2/Downstream/2785418;
Nearest TSS
ENST00000527297/Upstream/2958; ENST00000311413/Downstream/1481;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3379, chr11-CpG: 102/Downstream/1898
Upstream sequence
tcatttcctgggctcatatgatcctcctgcctcagcctcccaagtatctgggaccacaggcacacaccaccatgcctggctaatttttttattttctgta
Downstream sequence
gagacagggtcaccctatgttgtccaaggtggtcctgaactcctcacctccagagatcctcctgccttggcctcccaaagcaccgagattacaggtgtga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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