Basic Information
VIS ID
TVIS44026619
Fusion event
HTLV-1-OR51E2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
4704861/4683631 (Hg38)
End
4704861/4683631 (Hg38)
Orient
-
Location type
Intronic
Target gene
OR51E2
miRNAs that regulate target gene
hsa-mir-1303 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-542-3p ; hsa-mir-4252 ; hsa-mir-4299 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1292-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-6771-5p ; hsa-mir-7977 ; hsa-mir-3682-5p ; hsa-mir-298 ; hsa-mir-1827 ; hsa-mir-554 ; hsa-mir-6746-5p ; hsa-mir-5690 ; hsa-mir-2114-5p ; hsa-mir-5588-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p
Nearest miRNA
hsa-mir-210/Upstream/827490; hsa-let-7a-2/Downstream/2551135;
Nearest TSS
ENST00000527297/Upstream/40211; ENST00000322110/Downstream/1461;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/75331, chr11-CpG: 32/Downstream/1550907
Upstream sequence
AGAGATGAAGGTGCTGGCAGGACACTGGTGAGTACCTCCGCACCTGAAAGCTTCTTCCAAGGCCATTTTAATTGCATCCAAGGATAGTTTGAGTTGAGTC
Downstream sequence
CTTACTTTGGAGAAGTATTATTAATTTTACAATGATATTTTTAGAGCTTTGTCTTTCCTGAAACTTGTGCCAACAAGTCATTCATCTCAGGGGAGACATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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