Basic Information
VIS ID
TVIS44026668
Fusion event
HTLV-1-EMSY integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76184374/76473330 (Hg38)
End
76184374/76473330 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
EMSY
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-657 ; hsa-mir-329-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p
Nearest miRNA
hsa-mir-10392/Upstream/1138144; hsa-let-7a-2/Downstream/2928692;
Nearest TSS
ENST00000527297/Upstream/26391; ENST00000531998/Downstream/40067;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/27547, chr11-CpG: 92/Downstream/197075
Nearest cancer related gene
EMSY(OG, No orient, 0)
Upstream sequence
ATAAGAGGTAGGAGGAAGAAGATGGTTTCAAGGATATGCCATTTGCTTTTTCTTCAGTCTCCTACAtttttcttttctttttttttttctcgttgagaca
Downstream sequence
gggtctcgctctgtcacccaggctggagtgcagtggagcaatcttggctcactgcaacctccacctcccgggcttaagtgatcctcccacctcagccttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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