Basic Information
VIS ID
TVIS44026683
Fusion event
HTLV-1-GRM5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
88553854/88820686 (Hg38)
End
88553854/88820686 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRM5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-510-3p ; hsa-mir-6815-3p ; hsa-mir-513b-5p ; hsa-mir-4719 ; hsa-mir-892b ; hsa-mir-582-3p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548n
Nearest miRNA
hsa-mir-10392/Upstream/644093; hsa-let-7a-2/Downstream/1735088;
Nearest TSS
ENST00000527297/Upstream/308938; ENST00000526139/Downstream/226684;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/311292, chr11-CpG: 40/Downstream/245095
Upstream sequence
aaatagctttgcctctcagagcactgaattgctaactgatagaaatgcagaaaacattttttaatttgttaatttgtgatgaaaattaaaggaaataatg
Downstream sequence
tatacaaaatatttcgtaaatgtctaacTCCAAATGTTACCTCTCTATGTCTTGTTTTGTTATCATCTCACTTTCCTCTGTGAAACAGAATGAAGTATTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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