Basic Information
VIS ID
TVIS44026696
Fusion event
HTLV-1-MAML2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
96019577/96286413 (Hg38)
End
96019577/96286413 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAML2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-218-5p ; hsa-mir-6868-3p ; hsa-mir-6715b-3p ; hsa-mir-3605-3p ; hsa-mir-205-5p
Nearest miRNA
hsa-mir-10392/Upstream/1819833; hsa-let-7a-2/Downstream/55025;
Nearest TSS
ENST00000527297/Upstream/192893; ENST00000332349/Downstream/56767;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/362212, chr11-CpG: 75/Downstream/102959
Nearest cancer related gene
MAML2(OG, No orient, 0)
Upstream sequence
agtcctgtcggagggagcagggggagggagagcatcaggaagaataactaatggatgccaggtttaatacctaggtggtgggttgatctgtgcagcaaac
Downstream sequence
caccatggcacatgtttacctatgtaacaaacttgcacattctgcacatgtacccctgaactcaaacattgaagaaaaagaaaGGAATAAGAATCCCACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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