Basic Information
VIS ID
TVIS44026722
Fusion event
HTLV-1-RPH3A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
113168166/112730361 (Hg38)
End
113168166/112730361 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12D
Target gene
RPH3A
miRNAs that regulate target gene
hsa-mir-106a-5p ; hsa-mir-7106-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-765 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-5197-3p ; hsa-mir-574-5p ; hsa-mir-493-5p ; hsa-mir-4666a-5p ; hsa-mir-6867-5p ; hsa-mir-3177-5p ; hsa-mir-124-5p ; hsa-mir-3650 ; hsa-mir-4455
Nearest miRNA
hsa-let-7i/Upstream/35185; hsa-mir-1178/Downstream/428752;
Nearest TSS
ENST00000382841/Upstream/138801; ENST00000549769/Downstream/60788;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/154636, chr12-CpG: 37/Downstream/208019
Nearby gene
MIR1302-1(-35185) ;
Upstream sequence
cagaccaatgcaCTGGTTGAGGTCAACACGGAGATGCACCATTAGACTTGCTGTccagctgcagggagtgcagccaactgatggtctccagctgttagcc
Downstream sequence
ccatcaggggtagcctcagctgcagaaagccagcttgcccaaggtcatgcctttctctgggaagtcagtgtctgcatttgaaccaggtaggggtatgata
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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