Basic Information
VIS ID
TVIS44026735
Fusion event
HTLV-1-AACS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
125573723/125089177 (Hg38)
End
125573723/125089177 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
AACS
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-877-3p ; hsa-mir-191-5p ; hsa-mir-675-5p ; hsa-mir-4466 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6793-3p ; hsa-mir-589-3p ; hsa-mir-3614-5p
Nearest miRNA
hsa-let-7i/Upstream/173518; hsa-mir-3612/Downstream/3204915;
Nearest TSS
ENST00000382841/Upstream/23743; ENST00000537477/Downstream/1836;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/3583, chr12-CpG: 18/Downstream/4625
Upstream sequence
GTCAGATGGTTAAGCAGCCTCCCCTGGGCACCGAGTCCTGCCCTGACCCTGGGGGTGACAGTGTTGAGATGCTTCAGTTTACGCTCATAGCCAAGTCTCA
Downstream sequence
TCTTCGCTGCAAACTCAGCCAACACCAACCATCTGCCGGATGTGGGTGGAACCCCATGGTGGTGTGACCCCTGCCCCTTGGATGCTTATGGCCCAGCAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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