Basic Information
VIS ID
TVIS44026798
Fusion event
HTLV-1-NR4A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
52443240/52049456 (Hg38)
End
52443240/52049456 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
NR4A1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-196a-5p ; hsa-let-7d-5p ; hsa-mir-93-5p ; hsa-mir-124-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/1815244; hsa-let-7i/Downstream/849433;
Nearest TSS
ENST00000382841/Upstream/5617; ENST00000562373/Downstream/1946;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/11642, chr12-CpG: 87/Downstream/1313
Nearest cancer related gene
NR4A1(TSG, No orient, 0)
Upstream sequence
CTGTGGTGGACAGTGAGGCTTTAGAAAGAGGAGACAGGCAGGCTAATGGATGGTCTTCATGGGTGTGGGAAAGGAGGAGTGGTCACTGGGCGCAGGCAGT
Downstream sequence
TGGTCTGTGGGACCAGTGAGGCATGGGCTGTGGCTGGCAGTAGGAAAGCGGGAGAGgctgagtgcagtggctcatgcctataatcccagcactttgggaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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