Basic Information
VIS ID
TVIS44026852
Fusion event
HTLV-1-TMTC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
83286568/82892789 (Hg38)
End
83286568/82892789 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
TMTC2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4470 ; hsa-mir-561-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251
Nearest miRNA
hsa-let-7i/Upstream/1734328; hsa-mir-1178/Downstream/3852279;
Nearest TSS
ENST00000382841/Upstream/134234; ENST00000550279/Downstream/278801;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/204922, chr12-CpG: 17/Downstream/2018632
Upstream sequence
TCTCTCTTCCTCTCTACATCCCCGATCACTTCCACCACAAGATATTGTAATAGAATGTTCTTAGGCACATTTTAAAAATGGGCTTTTGGTACAAATTCAG
Downstream sequence
AATTCAGTTGTCTTTCAAGATCAGTCTTCTTTATCCATGATATCTTGTCTCCTTTATCTTTGCCAAATGGTGTTTCTCACTTGTATAATCTAAGAGTACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate