Basic Information
VIS ID
TVIS44026866
Fusion event
HTLV-1-PLXNC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
94582297/94188521 (Hg38)
End
94582297/94188521 (Hg38)
Orient
+
Location type
Intronic
Target gene
PLXNC1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-4719 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-299-5p ; hsa-mir-222-3p
Nearest miRNA
hsa-let-7i/Upstream/7443372; hsa-mir-1178/Downstream/373268;
Nearest TSS
ENST00000382841/Upstream/2477; ENST00000546659/Downstream/37968;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1423, chr12-CpG: 79/Downstream/271039
Nearest cancer related gene
PLXNC1(TSG, No orient, 0)
Upstream sequence
aagccgattctcctgccgcagcctcccgagtagctgggattaccggtacgtgccaccatgcccgactaatttttgtatttttagtagagatggggtttca
Downstream sequence
ccatgttggccaggttggtctcgaactcctgacctcaggtgatccgcctgcctcagcctcccaaattgccaggattacagccgtgagccaccacgcccag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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