Basic Information
VIS ID
TVIS44026943
Fusion event
HTLV-1-RCBTB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
50157071/49582935 (Hg38)
End
50157071/49582935 (Hg38)
Orient
+
Location type
Intronic
Target gene
RCBTB1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-328-3p ; hsa-mir-26a-5p ; hsa-mir-539-5p ; hsa-mir-6831-3p ; hsa-mir-2355-5p ; hsa-mir-452-3p ; hsa-mir-136-5p ; hsa-mir-342-3p ; hsa-mir-6793-3p ; hsa-mir-1285-5p ; hsa-mir-6826-3p ; hsa-mir-5192 ; hsa-mir-6882-3p ; hsa-mir-5189-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-3691-3p ; hsa-mir-4768-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-2276/Upstream/5386735; hsa-mir-1267/Downstream/413480;
Nearest TSS
ENST00000623511/Upstream/15612; ENST00000490932/Downstream/2648;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/86352, chr13-CpG: 80/Downstream/2315
Upstream sequence
AAAGAGTTAGGCTTTTTGCTAAGAGTAAGAGGGGAGGTAGCAATAAACAGTGGAGTGGAggccgggtgtggttgctcacgcctgtaatcccaacattttg
Downstream sequence
ggaggccaaggcgggaggactgcttgaggctaggtgttcaagaccagcctgggcaacatagggagaccctgtctctacaaaaaataaaaaaattagtcga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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