Basic Information
VIS ID
TVIS44026971
Fusion event
HTLV-1-MZT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
73286626/72712488 (Hg38)
End
73286626/72712488 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
MZT1
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-93-5p ; hsa-mir-4282 ; hsa-mir-1-5p ; hsa-mir-590-3p ; hsa-mir-548c-3p ; hsa-mir-6507-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-31-5p ; hsa-mir-4424 ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-5186 ; hsa-mir-4307 ; hsa-mir-586
Nearest miRNA
hsa-mir-1297/Upstream/6494164; hsa-mir-1267/Downstream/4985524;
Nearest TSS
ENST00000623511/Upstream/845296; ENST00000618209/Downstream/15199;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/844844, chr13-CpG: 91/Downstream/14604
Upstream sequence
agtgatccttctgctttggcctcccaaagtgctggtattacaggcgtgagccagcacgcctagcTGAAACACCCTAGTTTTAATGTGATGCTAGTATACT
Downstream sequence
GTTTCTAGATCATAGGAGAAATGCATTTTAAGAGGCTTTGTGTATGTGAGAGACAGATTTTCCATTCAAATAGTCAACACTTTCTGATTCAGTGTATCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate