Basic Information
VIS ID
TVIS44027002
Fusion event
HTLV-1-ABCC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
95814458/95162204 (Hg38)
End
95814458/95162204 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
ABCC4
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-324-5p ; hsa-mir-23b-3p ; hsa-mir-3924 ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-8064 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-1277-5p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p
Nearest miRNA
hsa-mir-1297/Upstream/2671984; hsa-mir-1267/Downstream/1265025;
Nearest TSS
ENST00000623511/Upstream/13244; ENST00000376855/Downstream/139098;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/159053, chr13-CpG: 120/Downstream/138802
Upstream sequence
CACTGTTATTTAACCTCTGAAAGCAGCTCAAATTCCTAACTCCATCAACGGGCATTATCCTTAGCCTGCCATCCTACACGAACATAATAGAACATAATAG
Downstream sequence
ATTTCCTTCTTCCTTTAGTTTCCACATAGTCCATCAGTTGGAAGGTAAACACCTAACAGATTTAGATTTCTTAGCAAGCGATCGATGAAATAAACACCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate