Basic Information
VIS ID
TVIS44027007
Fusion event
HTLV-1-STK24 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
99150095/98497841 (Hg38)
End
99150095/98497841 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
STK24
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-877-3p ; hsa-mir-186-5p ; hsa-mir-218-5p ; hsa-mir-578 ; hsa-mir-29b-2-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-140-5p
Nearest miRNA
hsa-mir-1297/Upstream/289241; hsa-mir-1267/Downstream/858290;
Nearest TSS
ENST00000623511/Upstream/31280; ENST00000434547/Downstream/21426;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/22751, chr13-CpG: 180/Downstream/78249
Upstream sequence
CACCTTCCTCCCATCCCTGGCGCAGAGCTGGGTGGATACCAGGATGTACAGAGAAAACTGGCACAGCAATGGAAAAACAACAGGGTACAGCGTCCTGGGG
Downstream sequence
ACAGATGCTGTGAACTGTAACACTAACTCTCTAAAGGAATCTACCCTCAATTCACCAAGAAAGACCAAGTGGGACTGGCTGCACTCAGCAACTGAGCCAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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