Basic Information
VIS ID
TVIS44027077
Fusion event
HTLV-1-MDGA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
48036629/47567426 (Hg38)
End
48036629/47567426 (Hg38)
Orient
+
Location type
Intronic
Target gene
MDGA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p
Nearest miRNA
hsa-mir-208a/Upstream/10615035; hsa-mir-1185-1/Downstream/193569;
Nearest TSS
ENST00000550708/Upstream/224192; ENST00000557531/Downstream/59099;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/915470, chr14-CpG: 186/Downstream/106804
Upstream sequence
AAGCTTTACTTATGGCAAGCTAAAATGAGGAACATAACAACTGAAGGAAAAACACTTATCATACATTATCCTAGAAATGCTACATGTTGAATGACACACT
Downstream sequence
CTAGCAACCATTCAACATTTGCTTGCCCAAACAAGCAGCAATACTGTTTGTCTAGAAACTAAATTTCATCTTTCTGAGCTCATTCCAACTATGACAGAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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