Basic Information
VIS ID
TVIS44027108
Fusion event
HTLV-1-TMEM229B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
67947867/67481150 (Hg38)
End
67947867/67481150 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
TMEM229B
miRNAs that regulate target gene
hsa-mir-433-3p ; hsa-mir-7154-5p ; hsa-mir-1206 ; hsa-mir-5008-5p ; hsa-mir-8060 ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-4257 ; hsa-mir-1197 ; hsa-mir-6840-3p
Nearest miRNA
hsa-mir-208a/Upstream/39220; hsa-mir-1185-1/Downstream/5035670;
Nearest TSS
ENST00000550708/Upstream/13804; ENST00000561456/Downstream/7582;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/7197, chr14-CpG: 95/Downstream/33647
Upstream sequence
gaggctgaggtgggagaatagcttgaggccaggagttcgagaccagcctgggcaacatagcgagaccaccatctctacaaaaagaaaaaaaagtaggctg
Downstream sequence
gtttgatgtggtgtgcctgtagtcccagacgctaaggcaggaggatcccttgagttcaagagtttgaggctacagtgagctatgattgtgccactgcact
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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