Basic Information
VIS ID
TVIS44027142
Fusion event
HTLV-1-CCDC88C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
91848861/91382517 (Hg38)
End
91848861/91382517 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCDC88C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-23b-3p ; hsa-mir-1-3p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-574-5p ; hsa-mir-3659 ; hsa-mir-6818-5p ; hsa-mir-218-5p ; hsa-mir-4658 ; hsa-mir-6790-5p ; hsa-mir-6867-5p ; hsa-mir-636 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-191-5p ; hsa-mir-1236-5p ; hsa-mir-4693-3p ; hsa-mir-922 ; hsa-mir-330-3p ; hsa-mir-5586-3p ; hsa-mir-5197-3p ; hsa-mir-424-5p ; hsa-mir-15a-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-497-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1260a/Upstream/14116227; hsa-mir-1185-1/Downstream/2565709;
Nearest TSS
ENST00000550708/Upstream/43661; ENST00000557524/Downstream/26241;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/78442, chr14-CpG: 16/Downstream/34500
Upstream sequence
TCCCCAGCTTATCTGGACTCTAAATTGGCCTTCTTTGTCAGGAATAACAGACCCTGAAAGGTTCTTCAAAGTCAGGTCCCTAAGAAAGCTGTTCCATCTC
Downstream sequence
CAGCTCAGCGTGTTTCCCTTTGTTCTACAGGACATGGGTCCTACAGACACCATCTAGCAGGTGAGGCAGAGATGACCCAGAGAAGACGGAGAAATACACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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