Basic Information
VIS ID
TVIS44027146
Fusion event
HTLV-1-BTBD7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.12
Reference genome
GRCh37/hg19
Start
93721176/93254830 (Hg38)
End
93721176/93254830 (Hg38)
Orient
-
Location type
Intronic
Target gene
BTBD7
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-218-5p ; hsa-mir-21-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-3658 ; hsa-mir-374a-5p ; hsa-mir-142-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-887-3p ; hsa-mir-3653-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-1248 ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1260a/Upstream/15988540; hsa-mir-1185-1/Downstream/693396;
Nearest TSS
ENST00000550708/Upstream/36149; ENST00000342144/Downstream/39098;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/30911, chr14-CpG: 117/Downstream/77533
Upstream sequence
cctaaggtggtgtgaggattaaatgagggcaatgcagatgaaagcacctagtacagtgcttagcacatactaagAGAGCATGAAAGTTAAGAGTCATTGT
Downstream sequence
TAGCAAACCTTTGTTGGGGACTTACGATGTGTTAGGCACGGAGTTAAGAGCAGAGGTATATATTTCCTAACCAAAGTTCTAAAATACTTTTCTAAACTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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