Basic Information
VIS ID
TVIS44027232
Fusion event
HTLV-1-CD276 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
73998671/73706330 (Hg38)
End
73998671/73706330 (Hg38)
Orient
+
Location type
Intronic
Target gene
CD276
miRNAs that regulate target gene
hsa-mir-29a-3p ; hsa-mir-29c-3p ; hsa-mir-335-5p ; hsa-mir-1301-3p ; hsa-mir-421 ; hsa-mir-92a-3p ; hsa-mir-28-5p ; hsa-let-7a-5p ; hsa-mir-1260b ; hsa-mir-187-3p ; hsa-mir-29b-3p ; hsa-mir-328-5p ; hsa-mir-4323 ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-4651 ; hsa-mir-486-3p ; hsa-mir-541-3p ; hsa-mir-5682 ; hsa-mir-608 ; hsa-mir-654-5p ; hsa-mir-6751-5p ; hsa-mir-6752-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-6795-5p ; hsa-mir-6803-5p ; hsa-mir-6835-5p ; hsa-mir-6842-5p ; hsa-mir-6871-3p ; hsa-mir-6885-5p ; hsa-mir-6887-5p ; hsa-mir-7109-5p ; hsa-mir-7110-5p ; hsa-mir-7153-3p ; hsa-mir-767-5p ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-10393/Upstream/406351; hsa-mir-11181/Downstream/705027;
Nearest TSS
ENST00000557528/Upstream/2133; ENST00000559978/Downstream/3235;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/21416, chr15-CpG: 136/Downstream/45890
Upstream sequence
cagagcaagacactgtctcaaaaaataaataaaataaaaataaaGTGATTTCATTGAGGCCATTGTTGCCAAGCAcatttcacagacgaagaaactgagg
Downstream sequence
tccacagagaagggggaactttcccaaggtcacagactggcacagcggcTCTCAATCTTTGGGGGTCAGACCCTTCTTTGAAAATTGGATAAATGATCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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