Basic Information
VIS ID
TVIS44027269
Fusion event
HTLV-1-LITAF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
11677246/11583390 (Hg38)
End
11677246/11583390 (Hg38)
Orient
-
Location type
Intronic
Target gene
LITAF
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-375 ; hsa-mir-128-3p ; hsa-mir-7-5p ; hsa-mir-27a-3p ; hsa-mir-320a ; hsa-mir-8083 ; hsa-mir-936 ; hsa-mir-7151-5p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-4484 ; hsa-mir-3714 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-3978 ; hsa-mir-127-5p ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6744-5p ; hsa-mir-1287-5p ; hsa-mir-6134 ; hsa-mir-617 ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-4712-3p ; hsa-mir-320e ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-1225/Upstream/276863; hsa-mir-11401/Downstream/1136931;
Nearest TSS
ENST00000527434/Upstream/26654; ENST00000329565/Downstream/2983;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/89294, chr16-CpG: 118/Downstream/2762
Nearest cancer related gene
LITAF(TSG, No orient, 0)
Upstream sequence
TCACAGTGATTTGTGGAATGGAAAATGCTTCCATCGGGGAGTTGGGCTGCTCCCCCACAATCAGAGTGGGCAGTTTTCCTCTGGACTCCTGGTGAAACCA
Downstream sequence
CATCCCTAGTTTCCACGTGAATCACAGTTTTTCATCAAACAGTGCAAGGAGATCATTAATAAGACTGAGACTGCATTAGGATACAAAATTGTATGAACGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate