Basic Information
VIS ID
TVIS44027349
Fusion event
HTLV-1-CDH11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
65105886/65071983 (Hg38)
End
65105886/65071983 (Hg38)
Orient
-
Location type
Intronic
Target gene
CDH11
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-200c-3p ; hsa-mir-27b-3p
Nearest miRNA
hsa-mir-1225/Upstream/7299631; hsa-mir-11401/Downstream/2130338;
Nearest TSS
ENST00000527434/Upstream/12305; ENST00000562656/Downstream/230;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/120978, chr16-CpG: 230/Downstream/48770
Nearest cancer related gene
CDH11(TSG, No orient, 0)
Upstream sequence
CACTGCCAGCCTCAAGCTTGTGTCCACAAAAGCCAATCCCCTTTGCTGGGATCTATGCGCCACCGTTCCCGTCCCTCGTCCCTGCTGGGTAGTAGTAACT
Downstream sequence
GGCACCTGCATTCAGGCTGGCAGATGGAGAGGCCAGGCTTATTGATTCCAGTGCCTACTCACTCCACCATCACGAAGGTCATGGTGCAGCAGCTAGCCGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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