Basic Information
VIS ID
TVIS44027358
Fusion event
HTLV-1-RANBP10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67790052/67756149 (Hg38)
End
67790052/67756149 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
RANBP10
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-330-5p ; hsa-mir-615-3p ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-222-3p ; hsa-mir-6510-5p ; hsa-mir-3175 ; hsa-mir-6864-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-873-3p ; hsa-mir-6857-3p ; hsa-mir-4499
Nearest miRNA
hsa-mir-1225/Upstream/553754; hsa-mir-11401/Downstream/477277;
Nearest TSS
ENST00000527434/Upstream/36728; ENST00000562633/Downstream/50369;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/36606, chr16-CpG: 69/Downstream/50223
Upstream sequence
TGCATTGTCACTCAGACAGAAAGTCACAGTCACAGAAATGCCAGGGTGGCTGCAGAAATCATTTATCACCTTGGCACTCCCAGGTAACATCCCTGGACAG
Downstream sequence
TGCCCTAGAGATGGAAGACTCCTGTAGGGTGCCAGGGACTCCAGCGTGACCGTTCCAGCAGCCCACCCATGCCACTACCATCTGCCAGGGCAGATCCAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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