Basic Information
VIS ID
TVIS44027396
Fusion event
HTLV-1-SPIRE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
89914379/89847971 (Hg38)
End
89914379/89847971 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPIRE2
miRNAs that regulate target gene
hsa-mir-6778-3p ; hsa-mir-3137 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-4469 ; hsa-mir-5193 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-498 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4532 ; hsa-mir-1247-3p
Nearest miRNA
hsa-mir-11401/Upstream/1131634;
Nearest TSS
ENST00000527434/Upstream/19273; ENST00000561883/Downstream/1895;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/12707, chr16-CpG: 57/Downstream/2271
Upstream sequence
GGTTGGAGTTAACCCTTTCAGTAATGTGATCAGGAAAAGCAGGGAGTGGCCTAGAGGGGCTGGGTGCTGCTGTGGACCGTGTGGGGGTTGGGGGCTTTGC
Downstream sequence
TGCTTCCTCCCTCTGTCTGTCCTGTGCCACGAGGCACAATCGGAGCCACGCGACCAGGGACAGCACGAGCTGAGGCCAGCCCCACCCGGAGCAGGTGGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate