Basic Information
VIS ID
TVIS44027407
Fusion event
HTLV-1-HS3ST3B1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
14230905/14327588 (Hg38)
End
14230905/14327588 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA17A
Target gene
HS3ST3B1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-4477a ; hsa-mir-4704-3p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-335-3p ; hsa-mir-452-3p ; hsa-mir-539-3p ; hsa-mir-5585-5p ; hsa-mir-485-3p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-1253/Upstream/783942; hsa-mir-10226/Downstream/924039;
Nearest TSS
ENST00000595228/Upstream/253; ENST00000436469/Downstream/46551;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/18016, chr17-CpG: 35/Downstream/17486
Upstream sequence
TAAGTTCAAGACTTTTATGGGTATAGCCACTTAATGTCATTGCGTCACTTAATGTAATGGGTGTGATGATACATGTATGTGTCATCTTTGGACATCTTTG
Downstream sequence
GACATCAGGATACTGGGACCATCACCCTTTTGAATCCTGGCCCCACCTGTTTATTATTCCAAGTTGCCCTTGATTCACCCCTGAGTTTCTTGACATATTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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