Basic Information
VIS ID
TVIS44027438
Fusion event
HTLV-1-AP2B1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
33934750/35607731 (Hg38)
End
33934750/35607731 (Hg38)
Orient
-
Location type
Intronic
Target gene
AP2B1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-532-3p ; hsa-mir-615-3p ; hsa-mir-106b-5p ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-19b-3p ; hsa-mir-188-5p ; hsa-mir-623 ; hsa-mir-4780 ; hsa-mir-6866-3p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-656-5p ; hsa-mir-6780b-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-214-3p ; hsa-mir-31-5p ; hsa-mir-3619-5p ; hsa-mir-3665 ; hsa-mir-3688-5p ; hsa-mir-424-5p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-497-5p ; hsa-mir-503-5p ; hsa-mir-646 ; hsa-mir-6809-5p ; hsa-mir-6815-5p ; hsa-mir-6838-5p ; hsa-mir-6865-5p ; hsa-mir-761
Nearest miRNA
hsa-mir-1180/Upstream/3257529; hsa-mir-10226/Downstream/1426014;
Nearest TSS
ENST00000595228/Upstream/13700; ENST00000591561/Downstream/106;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/10606, chr17-CpG: 74/Downstream/123799
Upstream sequence
ACTCCAGGTACTTATTTCAAGCCCAGACCAGCTCCTGTGCTCCCCTTTGTTTTCTTGGCTGCAGGCCACAGAAATCTAGCTCTCTTTTCTATTTGATGTT
Downstream sequence
TAGGAACTCACTGTGGAGTAGGGCACGGTCTTTACAGCTCCTCttttttttttttttttttttCCTGTGCCGGAATACAAGCCCAAAAGCTTTTCCTGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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