Basic Information
VIS ID
TVIS44027492
Fusion event
HTLV-1-PRKAR1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
66489476/68493335 (Hg38)
End
66489476/68493335 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRKAR1A
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-1296-5p ; hsa-mir-324-3p ; hsa-mir-204-5p ; hsa-mir-96-5p ; hsa-mir-25-3p ; hsa-mir-24-2-5p ; hsa-mir-24-1-5p ; hsa-mir-6504-3p ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-323a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-552-5p ; hsa-mir-3658 ; hsa-mir-7515 ; hsa-mir-580-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-1246
Nearest miRNA
hsa-mir-10226/Upstream/68787; hsa-mir-1250/Downstream/606207;
Nearest TSS
ENST00000595228/Upstream/35822; ENST00000589309/Downstream/18445;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/35339, chr17-CpG: 130/Downstream/18314
Nearest cancer related gene
PRKAR1A(TSG, No orient, 0)
Upstream sequence
acacgtttacctatggaacaaacctacacatcctgcccatgtacccctgaacttaaaagttgaagggaaaagaaagctttagagcaggaacaaaaggaag
Downstream sequence
gaaaatacacttggaagagggccaagcaggcaacttgaaaggcaagtgcTGTGTAATATTTTTTAAAAGTTAAGTTGTCCATATAAAAAAATTAAATAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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