Basic Information
VIS ID
TVIS44027497
Fusion event
HTLV-1-MAP2K6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
67440694/69444553 (Hg38)
End
67440694/69444553 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAP2K6
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-145-5p ; hsa-mir-29b-3p ; hsa-mir-3149 ; hsa-mir-411-5p ; hsa-mir-4775 ; hsa-mir-4735-5p ; hsa-mir-6832-5p ; hsa-mir-6872-3p ; hsa-mir-590-3p ; hsa-mir-8055 ; hsa-mir-1304-5p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-3166 ; hsa-mir-6804-5p ; hsa-mir-922 ; hsa-mir-1324 ; hsa-mir-1178-5p ; hsa-mir-5587-5p ; hsa-mir-6769a-3p ; hsa-mir-625-3p ; hsa-mir-1305 ; hsa-mir-302a-5p ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-10226/Upstream/344897; hsa-mir-1250/Downstream/5304060;
Nearest TSS
ENST00000595228/Upstream/29719; ENST00000588110/Downstream/57202;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/116857, chr17-CpG: 87/Downstream/724219
Upstream sequence
agaactagaatcagaagcaatccagctggagtgaagccccgaaacatatcgaaggaaggggtctggtgcaatataacacagctaccaccagttcaccaaa
Downstream sequence
ctgctgccaataaagcctccccaaccggatggagctgctgctatcattgtcaagtcccaaaatggatcctttgcagtctctccatgtctgcatcactggg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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