Basic Information
VIS ID
TVIS44027510
Fusion event
HTLV-1-TTYH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
72211027/74214888 (Hg38)
End
72211027/74214888 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTYH2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-215-5p ; hsa-mir-548n ; hsa-mir-555 ; hsa-mir-6073 ; hsa-mir-651-3p ; hsa-mir-6753-5p
Nearest miRNA
hsa-mir-10226/Upstream/5115232; hsa-mir-1250/Downstream/533725;
Nearest TSS
ENST00000595228/Upstream/1374; ENST00000578825/Downstream/728;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/737, chr17-CpG: 27/Downstream/59274
Upstream sequence
GGCCTCTCCCTGTGTCAAGTTCTCCAGATATGGGACAGATCAGGGCAAAGCAGGGCCTCTTGGAGGGAATCCTGATCCAGTGTGAGGTGCCCAAGCGCCA
Downstream sequence
GTGACAGGGAGTCTAATAATAACCCCTGACGACCCGGCTGCCATCAGGCCCAGGCAGATGGTGCCTGCCCTACCAGAGGGAGGGGAGCATCAGGACCCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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