Basic Information
VIS ID
TVIS44027538
Fusion event
HTLV-1-ROCK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
18624625/21044664 (Hg38)
End
18624625/21044664 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROCK1
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-584-5p ; hsa-mir-124-3p ; hsa-mir-1280 ; hsa-mir-148b-3p ; hsa-mir-335-5p ; hsa-mir-148a-3p ; hsa-mir-135a-5p ; hsa-mir-145-5p ; hsa-mir-340-5p ; hsa-mir-4662a-5p ; hsa-mir-4753-5p ; hsa-mir-6507-5p ; hsa-mir-6768-3p ; hsa-mir-548aw ; hsa-mir-5093 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3688-3p ; hsa-mir-300 ; hsa-mir-506-3p ; hsa-mir-584-3p ; hsa-mir-126-3p ; hsa-mir-144-5p
Nearest miRNA
hsa-mir-3156-2/Upstream/6214422; hsa-mir-1-2/Downstream/638854;
Nearest TSS
ENST00000575820/Upstream/61881; ENST00000579454/Downstream/4547;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/5713489, chr18-CpG: 113/Downstream/66315
Nearest cancer related gene
ROCK1(OG, No orient, 0)
Upstream sequence
TGTAGGCACAGCAACTGCACACAGGATTCAAGCAGTGTTTGTACAACAAATGAAACTATTCGTCTAATGAATAAATACGACCTATTCACTAATTAAAAGC
Downstream sequence
AAATTAAGTTACATATTTAAAAAATTAACATCAAAGTGTTTAACTCCTGGCACATACCTTAGAAAACTAGTTTACAAGTTTTACTTTTCAGAACACCATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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