Basic Information
VIS ID
TVIS44027590
Fusion event
HTLV-1-RAX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
56939337/59272105 (Hg38)
End
56939337/59272105 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
RAX
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-4266 ; hsa-mir-4467 ; hsa-mir-4634 ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-3141 ; hsa-mir-6749-3p ; hsa-mir-5193 ; hsa-mir-660-3p ; hsa-mir-361-3p ; hsa-mir-6814-5p ; hsa-mir-5196-3p ; hsa-mir-4428 ; hsa-mir-4316 ; hsa-mir-1294 ; hsa-mir-500b-5p ; hsa-mir-362-5p
Nearest miRNA
hsa-mir-1-2/Upstream/820947; hsa-mir-5011/Downstream/7809479;
Nearest TSS
ENST00000575820/Upstream/46438; ENST00000591331/Downstream/815;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/2510, chr18-CpG: 174/Downstream/287
Upstream sequence
TCACCCTCGATCACTACCTGCATTCCATTTCCACTCAGCAACCCCCAACCCCTTCCTGGCTATGTCTAATGAGCTGTCGGCCTCTTCATCTTGCAAGTCA
Downstream sequence
TTCCCATCTTCTATTTTGAGTTTAGAAGAGGGAAACCCCCAAAGGGGAGCTCGTACTACAAACTGGAACAGACTGCTTGAAGGGCGATGCACAGGGAACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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