Basic Information
VIS ID
TVIS44027609
Fusion event
HTLV-1-NFATC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
77167379/79407379 (Hg38)
End
77167379/79407379 (Hg38)
Orient
+
Location type
Intronic
Target gene
NFATC1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7b-5p ; hsa-mir-145-5p ; hsa-mir-4755-5p ; hsa-mir-5006-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-324-5p ; hsa-mir-3124-3p ; hsa-mir-4671-5p ; hsa-mir-6832-3p ; hsa-mir-143-3p
Nearest miRNA
hsa-mir-1-2/Upstream/6553997;
Nearest TSS
ENST00000575820/Upstream/6987; ENST00000590224/Downstream/40891;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/336, chr18-CpG: 85/Downstream/3048
Upstream sequence
GGTCAGTCCCAGAGCTGGCGTCTTGCAGCTGGGGCAGATCCTGGGGATGGTGTGTGTGTCCTGACCAGAGGCCAGGCTGGAGGCTGGAATTGGCGTCAGG
Downstream sequence
ATGCCCAGCTCCAGCTCCACCCCAGTCCCTGCCTGTGGCTCTGGGGAAAGAAAGACCTCCttattgatttattgatttattgatttgacagggtcttgct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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