Basic Information
VIS ID
TVIS44027622
Fusion event
HTLV-1-LSM4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
18431963/18321153 (Hg38)
End
18431963/18321153 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
LSM4
miRNAs that regulate target gene
hsa-mir-769-5p ; hsa-mir-423-3p ; hsa-mir-874-3p ; hsa-mir-6882-3p ; hsa-mir-146b-3p ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-7153-5p ; hsa-mir-7976 ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-18a-3p ; hsa-mir-4251 ; hsa-mir-4324 ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-3158-3p ; hsa-mir-421 ; hsa-mir-4297 ; hsa-mir-4721 ; hsa-mir-488-3p ; hsa-mir-505-3p ; hsa-mir-532-5p ; hsa-mir-5581-5p ; hsa-mir-5586-5p ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-676-5p ; hsa-mir-6849-3p ; hsa-mir-7159-5p
Nearest miRNA
hsa-mir-10395/Upstream/38992; hsa-let-7e/Downstream/65409;
Nearest TSS
ENST00000633603/Upstream/4894; ENST00000595066/Downstream/1907;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11227, chr19-CpG: 53/Downstream/1679
Upstream sequence
ACGACAGGGAACTGGAAGTGTGTATCCTGTGATGGCTTGTCCATTCTCGGCTACTCCTCCAGGAAACAGCTGGACAGCCAGGACTCTGGATGTTCAGAAG
Downstream sequence
GTGGGAAGGGGCTGAATGAAtgagttcacactttgcccacgcaccgttctacatactgggaatctagtcggaagaaaaacgaagatcctgctcccacaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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