Basic Information
VIS ID
TVIS44027644
Fusion event
HTLV-1-PDCD5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
33076048/32585142 (Hg38)
End
33076048/32585142 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PDCD5
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-10395/Upstream/12185788; hsa-let-7e/Downstream/2537558;
Nearest TSS
ENST00000633603/Upstream/273; ENST00000588622/Downstream/1503;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3240, chr19-CpG: 16/Downstream/20420
Nearest cancer related gene
PDCD5(TSG, No orient, 0)
Upstream sequence
TAGCTTGAGTTAGTTGAATGGGGTGATTAGATACCATTATTGCTATCACTAGATGAAATATTTGCTTAGGCTGAAAACACTTGAGATGTGTAAGAAGTGT
Downstream sequence
GAAGTTTATAAACCTAGAGAACTGTACTTTAATCCCTAGTAAAAGTACCAGGTCACTTCTCTTACCAAGATGTTCTCCAGGTGTGTATTAGGTAAGATTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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